Edie Falco leads as Nurse Jackie Peyton, a hard-working emergency room nurse hiding an addiction to prescription painkillers, with Eve Best as best friend Dr. Eleanor O’Hara and Merritt Wever as loyal but naïve nursing student Zoey Barkow.
Main cast
- Jackie PeytonEdie Falco1–7Main
- Dr. Eleanor O’HaraEve Best1–6Main
- Zoey BarkowMerritt Wever1–7Main
- Dr. Fitch ‘Coop’ CooperPeter Facinelli1–7Main
- Dr. Gloria AkalitusAnna Deavere Smith1–5Main
- Eddie WalzerPaul Schulze1–7Main
- Kevin PeytonDominic Fumusa1–7Main
- Grace PeytonRuby Jerins1–7Main
- Dr. Mike CruzBobby Cannavale6–7Main
- Charlie CruzAdam Ferrara6–7Main
Supporting cast
- Dr. William ‘Billy’… something?John ventimiglia1–2Supp
- Supp
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About this cast
Nurse Jackie is a dark-comedy medical drama that follows Jackie Peyton (Edie Falco), a gifted but deeply flawed emergency room nurse at a New York City hospital, as she balances her demanding job with a secret addiction to painkillers. The series ran for seven seasons on Showtime from 2009 to 2015 and was distributed in the UK via Sky Atlantic and NOW. Alongside Falco, the main cast includes Eve…
FAQs
Who plays the lead character Jackie Peyton in Nurse Jackie?
Edie Falco portrays the title character Jackie Peyton, a nurse battling addiction.
How many seasons of Nurse Jackie are there?
The series has 7 seasons, airing from 2009 to 2015.
Is Nurse Jackie available on any UK streaming service?
It previously streamed on Sky Atlantic and NOW, but availability may vary; check current listings on Netflix, Amazon Prime, or BBC iPlayer.
Sources & where to watch: IMDb · Wikipedia · Where to watch (JustWatch UK) · Updated June 2026